Clock CLIA Kit for Rat(Rattus norvegicus) | EIAab.comClock CLIA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Clock(Gene name) > Rat

Clock (Gene name),

Circadian locomoter output cycles protein kaput (Protein name ), CLOCK_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Clock;

Protein name:

Circadian locomoter output cycles protein kaput(rCLOCK);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with ARNTL is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Binds weakly ARNTL and ARNTL2 to form heterodimers which bind poorly to the E-box motif.

Function:

ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression. Acetylates primarily histones H3 and H4. Acetylates also a non-histone substrate: ARNTL. Plays a role in DNA damage response (DDR) signaling during the S phase.

Subcellular Location:

Cytoplasm Nucleus Chromosome Localizes to sites of DNA damage in a H2AX-independent manner. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent.

Protein Attributes:

Sequence length:

862

Sequence:

50:

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862:

DSLTDPSKVQ | PQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.205839

KEGG:

rno:60447

String:

Q9WVS9

Pfam:

PF00010

Uniprot:

Q9WVS9

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ELISA Kit for Rat rCLOCK

Cat.:

E15436m

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Packing:

96T

ELISA Kit for Rat rCLOCK

Cat.:

E15436r

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96T

ELISA Kit for Rat rCLOCK

Cat.:

E15436c

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96T

ELISA Kit for Rat rCLOCK

Cat.:

E15436h

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96T

CLIA Kit for Rat rCLOCK

Cat.:

U15436r

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Packing:

96T

CLIA Kit for Rat rCLOCK

Cat.:

U15436c

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Packing:

96T

CLIA Kit for Rat rCLOCK

Cat.:

U15436h

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MSDS:

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Packing:

96T

CLIA Kit for Rat rCLOCK

Cat.:

U15436m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat rCLOCK

Cat.:

P15436Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat rCLOCK

Cat.:

P15436Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat rCLOCK

Cat.:

P15436Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat rCLOCK

Monoclonal Antibody for Rat rCLOCK

Protein for Rat rCLOCK

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Phase-dependent induction by light of rat Clock gene expression in the suprachiasmatic nucleus."
Abe H. , Honma S. , Namihira M. , Tanahashi Y. , Ikeda M. , Yu W. , Honma K.
Brain Res. Mol. Brain Res.66:104-110(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);TISSUE SPECIFICITY;INDUCTION
tissue: Brain.

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